ncRNA name | rAR siRNA |
ncRNA Category | siRNA |
Disease name | diabetic cataract |
Species | Rattus norvegicus |
Tissues/Cell_line | rat lens epithelial cells (RLECs) |
Methods | siRNA transfection, Western blot, TUNEL assay, MTS assay, DCDHF diacetate assay, ELISA |
Expression pattern | associated |
Functional description | Both inhibition of rAR expression by rAR siRNA and inhibition of rAR activity by an ARI appeared effective in diminishing the changes of RLECs associated with high glucose levels. |
PubMed ID | 18835019 |
Year | 2008 |
Title | Attenuation of aldose reductase gene suppresses high-glucose-induced apoptosis and oxidative stress in rat lens epithelial cells. |
Drug-related ncRNA | NO |
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