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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic cataract
ncRNA name rAR siRNA
ncRNA Category siRNA
Disease name diabetic cataract
Species Rattus norvegicus
Tissues/Cell_line rat lens epithelial cells (RLECs)
Methods siRNA transfection, Western blot, TUNEL assay, MTS assay, DCDHF diacetate assay, ELISA
Expression pattern associated
Functional description Both inhibition of rAR expression by rAR siRNA and inhibition of rAR activity by an ARI appeared effective in diminishing the changes of RLECs associated with high glucose levels.
PubMed ID 18835019
Year 2008
Title Attenuation of aldose reductase gene suppresses high-glucose-induced apoptosis and oxidative stress in rat lens epithelial cells.
Drug-related ncRNA NO

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